We Played Timothy Leary's 1985 Video Game So You Don't Have To
Posted: 11/5/2026This video originally aired as Patreon-only content. Check us out on Patreon at www.patreon.com/psymposia
In female mice modeling schizophrenia, a single dose of psilocybin restored sensory filtering for days
Posted: 11/5/2026People with schizophrenia are usually excluded from psychedelic trials. A new mouse study suggests the picture is complicated: psilocybin amplified immediate reactions in a schizophrenia model but lastingly improved sensory filtering in females.
Setting may shape psilocybin’s effects on the brain, preliminary study suggests
Posted: 11/3/2026Healthy adults who took psilocybin in a calm room with music reported stronger mystical experiences than those dosed inside an MRI scanner. Their brain scans a week later also hinted at more synaptic change.
Single-Dose Psilocybin Lacks Lasting Behavioral Effects
Posted: 11/2/2026Does psilocybin produce lasting behavioral changes in mice? A multi-lab consortium discovered that while acute effects are reproducible, a single dose produces no lasting reductions in anxiety or depression-like behaviors 24 hours later.
A Medicalization-Only Model Limits the Psychedelic Experience
Posted: 11/2/2026Journalist Rich Haridy discusses his concerns with boxing psychedelics into a medicalized container.
The Hotline That Accidentally Built the World’s Biggest Database of Real Psychedelic Freakouts
Posted: 10/30/2026Forget lab coats and sterile clinics. The real story of how humans trip is being written one panicked 2 a.m. phone call at a time and the data is wild.
5-MAPB: The "Cleaner MDMA" That Demands More Respect Than It Gets
Posted: 10/29/2026Inside the benzofuran entactogen that promises MDMA-like warmth with less stimulation—and the serious pharmacological unknowns hiding behind the hype.
News coverage of psilocybin often outpaces the science, systematic review finds
Posted: 10/27/2026Researchers compared 70 psilocybin trial publications with 172 news articles. Both reported positive results at similar rates, but news coverage tended to present the benefits as established and rarely discussed the small, early-stage nature of the research.
Australian Bush Doofs and Psychedelic Commercialization (w/ Dr. Sam Douglas & Rich Haridy)
Posted: 10/25/2026Russell, Mike, and Neşe sit down with journalist Rich Haridy and Dr. Samuel Douglas to discuss bush doofs, Australian psychedelic commercialization, Entheogenesis Australis, Haridy's new book, and more.
Psilocybin Replaces Lost Synapses in Depressed Brains
Posted: 10/24/2026Does healing the brain with psychedelics require a "trip"? A new study shows psilocybin drives synaptic plasticity through Layer 5 pyramidal neurons independently of hallucinogenic signaling, opening the door to non-hallucinogenic depression therapeutics.
Psymposia's Psychedelic Patreon Pop Quiz
Posted: 10/22/2026This video was originally aired as Patreon-only content. Check us out on Patreon at www.patreon.com/psymposia
Beneath psilocybin’s apparent brain chaos, scientists find signs of a hidden order
Posted: 10/22/2026Psilocybin is often described as throwing the brain into disorder. A new study in Nature suggests that beneath the apparent chaos, brain activity becomes organized around what a person is doing, especially in those who feel a sense of unity.
The Top 10 Heavyweight Champions of Consciousness
Posted: 10/20/2026Forget the street-corner shrooms you bought from a guy named Dave. We're diving deep into the mycelial matrix to crown the true kings and queens of the cosmos.
Psymposia Aesthetics: Team Portrait Illustrations
Posted: 10/19/2026This video originally aired as Patreon-only content. Check us out on Patreon at www.patreon.com/psymposia
A single dose of psilocybin eased depression within days, but its edge over placebo faded within a year
Posted: 10/18/2026A single dose of psilocybin eased depression within days in a small Swedish trial, outperforming an active placebo for more than three months on patients’ self-ratings. By one year, however, the placebo group had largely caught up.
The Ultimate Guide to Preparing and Enjoying Psilocybin Mushroom Tea
Posted: 10/18/2026Sociedelic Sociedelic - Psychedelic Society Community and News The tea cup is the first altar you build before the journey begins. You don’t start by measuring mushrooms on a scale or setting a timer. You begin with water, and then heat, and then time — all of it working in tandem to coax the medicine into liquid form. That’s where this guide starts: […] The post The Ultimate Guide to Preparing and Enjoying Psilocybin Mushroom Tea appeared first on Sociedelic.
Psilocybin therapy has mostly reached the well-off. A small Oregon study tested a cheaper group model for low-income patients
Posted: 10/16/2026Most psychedelic research has drawn well-off participants. In a first-of-its-kind Oregon study, 19 low-income adults with depression completed group psilocybin therapy, and their average depression scores fell by more than half.
Psymposia Aesthetics: Right-Wing Psychedelia Collage
Posted: 10/16/2026This video was first aired as Patreon-exclusive content. Check out our Patreon at www.patreon.com/psymposia.
Psilocybin appears to strengthen this optical illusion, but LSD microdoses do not
Posted: 10/15/2026A small pilot study found that a high dose of psilocybin strengthened an illusion in which a striped pattern looks fainter inside a bold ring. Low doses of LSD did not do the same, though participants still reported subtle changes in how the world looked.
Psilocybin, LSD, and 2C-B leave different fingerprints on the brain, new study suggests
Posted: 10/14/2026Psilocybin, LSD, and 2C-B all act on the same serotonin receptor, so they are often treated as a single drug class. But brain scans in rats suggest each one shifts the brain’s energy use in its own way, both right away and a week later.
Psymposia Aesthetics: Volume #1
Posted: 10/13/2026This video originally aired on our Patreon. You can find us there at www.patreon.com/psymposia
LSD Microdosing Enhances Sustained Attention in Women
Posted: 10/12/2026A double-blind trial finds low-dose LSD microdosing significantly sharpens sustained attention and cuts attention lapses in women, but not in men.
Brain entropy during a psychedelic trip tracks later gains in insight and well-being
Posted: 10/12/2026The more disordered a person’s brain activity became during their first psilocybin trip, the more their well-being tended to improve a month later, according to a small, exploratory study of healthy volunteers.
The Deluded Beliefs of Psychedelic Therapy Advocates
Posted: 10/6/2026The crew discusses two presenters at the September 14, 2026 FDA public hearing on psychedelics, and the way that Silicon Valley and new age pseudoscience are coming together to create the back bone of the psychedelic therapy industry's ideology.
Psilocybin shows early promise for lingering Lyme disease symptoms
Posted: 10/3/2026Up to one in five Lyme patients keep experiencing symptoms after antibiotics. A new pilot study suggests psilocybin-assisted therapy might help, with symptom burden 40% lower six months later, though larger controlled trials are needed.
Psymposia Mailbag (September 2026)
Posted: 10/2/2026The crew reads comments on their recent conversion therapy, Reggie Watts, and Alex Novell videos.
MAHA Summit — Brought to You by Psychedelic Pharma
Posted: 9/28/2026Normie, Mike, and Neşe discuss the upcoming MAHA Summit and its psychedelic pharmaceutical sponsors.